PREVALENCE OF α-THALASSEMIA (α-THAL) IN CHILDREN WITH SICKLE CELL DISEASE (SS) AND CEREBROVASCULAR ACCIDENT (CVA)

Prevalence of −α and ααα alleles in sickle cell trait and β-thalassemia patients in Mexico

The aim of this study was to determine the frequency of α-globin gene mutations in three groups of Mexican unrelated individuals. The first two groups were normal and sickle cell trait individuals from the Costa Chica region, a place with a 12.8% frequency of HbS carriers, and the third group comprised of Mexican mestizo patients with β-thalassemia. We searched for −α and −α α-thalassemia delet...

Stroke (CVA, Cerebrovascular Accident) — Causes and Symptoms

An infant Presenting with Cerebrovascular Accident was Diagnosed as a Sickle Cell Disease Patient: a Case Report

Sickle cell disease (SCD) is a known inherited hemoglobin disorder featured by the presence of sickle shaped erythrocytes in the blood. It can cause cerebrovascular accident (CVA) in adults and children and is responsible for the majority of the strokes in children. Repeated blood transfusion are often required in an attempt to dilute blood thus reducing the risk of vaso-occlusion and stroke in...

Alpha-thalassemia protects against cerebrovascular disease in children with sickle cell anemia.

1Foundation and Center for Hematology and Hemotherapy of Minas Gerais (HEMOMINAS), Belo Horizonte MG, Brazil; 2Medical School/Nupad, Department of Pediatrics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil. Correspondence: Marcos Borato Viana; Department of Pediatrics, Medical School of the Federal University of Minas Gerais; Avenida Alfredo Balena 190/267; 30130-100 Belo Hor...

Stroke (CVA, Cerebrovascular Accident) — Causes and Symptoms